Engineer - MES (PAS-X)

Job title: Engineer - MES (PAS-X)

Career level: C2

Are you ready to disrupt an industry and change lives? As a Engineer - MES (PAS-X) you'll play a vital role in AstraZeneca’s ambitious growth plans, working on AZ’s major investment projects around the globe, expanding existing manufacturing sites and building new greenfield sites to supply the medicines of the future. Your expertise will be used to ensure that we have the right IT to operate the manufacturing facilities to produce the medicines required by patients around the world. This will include integrating the sites into the supply chain, ensuring the quality of what’s produced, capturing data from the shop floor, driving productivity improvements, and all in a company that is at the innovative of using digital technology to deliver exceptional value. Whether working independently or leading a team of experts, your communication skills and cultural sensitivity will be key to delivering impactful reasons that make a real difference. Join us in shaping the future of healthcare through innovative solutions and standard processes.

Seeking a hands-on Technical Lead to drive deployment, support, and continuous improvement of MES, with a focus on Werum PAS-X. The role demands deep technical expertise, leadership, and a proactive approach in regulated manufacturing environments.

Part of a global IT team, this role supports MES and related applications critical to AstraZeneca’s manufacturing operations.

Main Responsibilities Of The Role Are

• Provide Technical Leadership: Deliver expert guidance and hands-on support for PAS-X system administration, trouble shooting, and performance optimization.
• multi-functional Collaboration: Work closely with Manufacturing, Quality, IT, and Automation teams to ensure seamless MES integration with ERP, LIMS, SCADA, and other enterprise systems.
• Incident & Problem Management: Lead the resolution of MES-related issues through root cause analysis and implementation of permanent corrective actions.
• Documentation & Compliance: Develop and maintain comprehensive technical documentation, including design specifications, configuration guides, and SOPs, ensuring alignment to GMP, GAMP5, and 21 CFR Part 11 standards.
• Team Mentorship: Guide and mentor junior engineers and support staff in MES best practices and PAS-X technical expertise.
• Change & Validation Management: Participate in change control processes, system upgrades, and validation activities to maintain system integrity and compliance.
• PAS-X Deployment: Manage end-to-end PAS-X MES solution deployments, encompassing requirements gathering, configuration, testing, validation, and launch support.
• System Performance & Stability: Ensure optimal performance and reliability of MES systems supporting AstraZeneca Manufacturing Operations, including identifying and implementing long-term solutions.
• MES Support Oversight: Oversee MES support functions, ensuring efficient and effective service delivery.
• Advanced Technical Support: Provide 2nd and 3rd line support for technical queries, bug fixes, and minor enhancements, in alignment with AstraZeneca standards and change control procedures.
• Continuous Improvement: Contribute to the design and implementation of initiatives aimed at enhancing system performance and operational efficiency.
• Project Leadership: Lead PAS-X project delivery efforts as needed, ensuring successful execution and stake holder alignment.
  
  

Essential Experience: (Must have skills)

• 6+ years of experience in MES implementation and support (L2/L3), with at least 4 years of hands-on experience with Werum PAS-X.
• 1+ years of demonstrated experience managing and supporting a Manufacturing Execution System, PAS-X would be an advantage.
• Solid understanding of manufacturing processes in pharmaceutical, biotech, or other regulated industries.
• Proficiency in PAS-X configuration, MBR design, and system integration.
• Experience with SQL, Oracle databases, and scripting using PowerShell and or other automation tools like MS PowerApps or Power Automate for automation and reporting.
• Familiarity with ISA-95, S88 standards, and integration with Level 2/3 systems.
• Excellent problem-solving, communication, and stake holder management skills.
• Demonstrable ability to lead technical teams and manage multiple priorities in a fast-paced environment.
• Knowledge on incident, problem, change and release management following ITIL processes.
• Experienced on IT Service Management tools like ServiceNow.
• 2+ years of prior experience working with DevOps and Scrum methodologies. Understanding in project management methodologies, tools, and guideline.
• Team skills, including the ability to establish and maintain effective working relationships with all levels within the organization, internally and externally and Effective engagement with senior leaders.
  
  

Educational Qualifications

• Undergraduate Degree: B. Tech / B.E. or an equivalent technical qualification.
• Postgraduate Degree: MBA or master’s degree is an added advantage.
• Certifications (Preferred):
• MES, Oracle Administration, or Windows Server Administration certification.
• ITIL v3 Foundation certification.
  
  

Candidate Expectations

• Demonstrates a collaborative mindset, actively supporting and maintaining business-critical applications.
• Eager to learn and adopt new skills, with a strong interest in emerging technologies.
• Capable of working independently as well as contributing effectively within a team environment.
• Possesses a logical and analytical approach to problem-solving.
• Communicates clearly and concisely, both in written and verbal forms.
• Exhibits strong communication and leadership abilities.
• Well-organized with excellent time management skills and remains composed under pressure.
• Brings strong interpersonal skills and the ability to collaborate across diverse teams and functions.
  
  

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

At AstraZeneca, we couple technology with an inclusive mentality to cross international boundaries and develop a leading ecosystem. Our diverse teams work closely at scale, bringing together the best minds globally to uncover new solutions. We think holistically about applying technology, building partnerships inside and out to drive simplicity and efficiencies that make a real difference. Here you can innovate, take ownership, experiment with innovative technology, and tackle challenges that have never been addressed before.

Ready to make an impact? Apply now to join our dynamic team!

Date Posted

30-Jan-2026

Closing Date

02-Feb-2026

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.