Research Scientist

Job Title: Sr. Research Scientist – Biochemistry

Location: Onsite, Wilmington, DE

Position Overview

We are seeking a highly skilled Sr. Research Scientist – Biochemistry to support drug discovery efforts through the design, development, and execution of biochemical and biophysical assays. This role will play a critical part in hit identification, validation, and mechanistic studies for small molecules and other therapeutic modalities.

Key Responsibilities

• Design, develop, and execute biochemical assays (e.g., FI, HTRF, FP) and biophysical assays (e.g., SPR, BLI, ITC, DSF)
• Conduct high-throughput screening (HTS) to evaluate compound libraries and characterize binding kinetics (IC₅₀, Kd, kon, koff)
• Troubleshoot assay performance, optimizing for robustness, reproducibility, and scalability
• Analyze and interpret experimental data using tools such as GraphPad Prism and Genedata
• Support protein expression and purification workflows using chromatography techniques (affinity, ion-exchange, size-exclusion)
• Operate and maintain lab instrumentation including plate readers and automated liquid handling systems
• Maintain accurate documentation using electronic lab notebooks (ELN) and contribute to technical reports and presentations

Required Qualifications

• Bachelor’s, Master’s, or Ph.D. in Biochemistry, Chemistry, Biophysics, Chemical Biology, or related field
• Strong foundation in enzymology and assay development
• Hands-on experience in protein purification and biochemical/biophysical characterization
• Proficiency with data analysis tools (GraphPad Prism, Genedata, or similar)
• Experience working in a laboratory setting with strong attention to detail and documentation