Clinical Fellow in Translational Research

We are seeking an ambitious and motivated early-career medical oncologist, or individuals with an interest in developing a career in medical oncology, to join The Christie NHS Foundation Trust in partnership with Cancer Research UK Manchester Institute as a Clinical Research Fellow. This exciting Translational Research fellowship is focused on advancing our understanding of the progression and evolution of pancreatic ductal adenocarcinoma from development through to metastasis.

The appointed fellow will be primarily based within the Systems Oncology team at CRUK MI, working closely with the Rapid Donation Tissue Collection Programme to enable timely collection & analysis of pancreatic tissue, in collaboration with the Manchester Cancer Research Centre Biobank.

This project leverages a uniquely Manchester-led initiative: The Christie’s Rapid Donation Tissue Collection Programme. This programme, unparalleled in the UK, allows access to fresh human pancreatic and metastatic tissue within hours of donation, enabling high-quality analysis all stages of PDAC development. We aim to determine the functional relationship of evolving PDAC & the desmoplastic microenvironment using state-of-the-art 3D imaging, histology & molecular profiling.

This role offers a unique opportunity to work within internationally renowned teams and contribute directly to translational pancreatic cancer research, while developing both laboratory & clinical research expertise.

This role offers a unique opportunity to work within internationally renowned teams and contribute directly to translational pancreatic cancer research, while developing both laboratory and clinical research expertise.

The successful applicant will also need to divide their time between research and a moderate clinical commitment; this may involve clinical research and audit activities, including protocol-writing. The post will be also based within the Department of Medical Oncology under the supervision of a consultant clinician. Within the department, they will coordinate patient identification and sample collection in collaboration with Medical Oncology, Surgery, and Gastroenterology teams at MFT. They will attend a weekly HPB and acute oncology clinic with flexibility depending on research priorities to assist in identifying research candidates, and to gain exposure to HPB medical oncology and clinical trials

They will attend appropriate clinics per week (a maximum of two research and two NHS clinics), and multidisciplinary meetings. In addition, they will participate in clinical research meetings and any other relevant trial planning or trial set-up meetings. Will also spend time reviewing clinical data, writing abstracts/manuscripts, planning new studies and attending educational meetings.

The Christie is one of Europe’s leading cancer centres, treating over 60,000 patients a year. We are based in Manchester and serve a population of 3.2 million across Greater Manchester & Cheshire, but as a national specialist around 15% patients are referred to us from other parts of the country.

We provide radiotherapy through one of the largest radiotherapy departments in the world; chemotherapy on site and through 14 other hospitals; highly specialist surgery for complex and rare cancer; and a wide range of support and diagnostic services. We are also an international leader in research, with world first breakthroughs for over 100 years.

We run one of the largest early clinical trial units in Europe with over 300 trials every year. Cancer research in Manchester, most of which is undertaken on the Christie site, has been officially ranked the best in the UK.

For further details / informal visits contact: Name: Dr Jamie Weaver Job title: Consultant Medical Oncologist Email address: [email protected]